Article
Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology.
Journal of cellular and molecular medicine - 1 Feb 2011
Zhu Yuyan, Obregon Demian, Hou Huayan, Giunta Brian, Ehrhart Jared, Fernandez Frank, Mori Takashi, Nikolic William, Zhao Yangbing, Morgan Dave, Town Terrence, Tan Jun
Abstract excerpt
Mutations in the presenilin-1 (PS1) gene are independent causes of familial Alzheimer's disease (AD). AD patients have dysregulated immunity, and PS1 mutant mice exhibit abnormal systemic immune responses. To test whether immune function abnormality caused by a mutant human PS1 gene (mhPS1) could modify AD-like pathology, we reconstituted immune systems of AD model mice carrying a mutant human amyloid precursor...
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