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Article

Overlapping open reading frames strongly reduce human and yeast STN1 gene expression and affect telomere function.

PLoS genetics - 1 Aug 2018

Torrance Victoria, Lydall David

Abstract excerpt

The levels of telomeric proteins, such as telomerase, can have profound effects on telomere function, cell division and human disease. Here we demonstrate how levels of Stn1, a component of the conserved telomere capping CST (Cdc13, Stn1, Ten1) complex, are tightly regulated by an upstream overlapping open reading frame (oORF). In budding yeast inactivation of the STN1 oORF leads to a 10-fold increase in Stn1...

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Identifiers

PMID: 30067734
DOI: 10.1371/journal.pgen.1007523
PMCID: PMC6089452

Genes

STN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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