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Article

Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload.

PloS one - 1 Jan 2018

Ye Lei, Su Liping, Wang Chenxu, Loo Szejie, Tee Guizhen, Tan Shihua, Khin Sandar Win, Ko Shijie, Su Boyang, Cook Stuart A

Abstract excerpt

Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic dysfunction when subjected to pressure-loading. However, the effects of TTNtv of the Z-disc are largely unexplored. A rat model of pressure-loaded heart is developed by trans-aortic constriction (TAC). Rats with TTNtv of the Z-disc were randomly assigned to TAC (Z-TAC) or sham-surgery (Z-Sham) and wildtype (WT)...

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Source

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Identifiers

PMID: 30063764
DOI: 10.1371/journal.pone.0201498
PMCID: PMC6067738

Genes

TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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