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Mechanisms of TTNtv-Related Dilated Cardiomyopathy: Insights from Zebrafish Models

25 Jan 2021

Abstract excerpt

Dilated cardiomyopathy (DCM) is a common heart muscle disorder characterized by ventricular dilation and contractile dysfunction that is associated with significant morbidity and mortality. New insights into disease mechanisms and strategies for treatment and prevention are urgently needed. Truncating variants in the TTN gene, which encodes the giant sarcomeric protein titin (TTNtv), are the most common genetic...

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PMID: 33504111
DOI: 10.3390/jcdd8020010

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