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Article

Cardiac titin and heart disease.

Journal of cardiovascular pharmacology - 1 Mar 2014

LeWinter Martin M, Granzier Henk L

Abstract excerpt

The giant sarcomeric protein titin is a key determinant of myocardial passive stiffness and stress-sensitive signaling. Titin stiffness is modulated by isoform variation, phosphorylation by protein kinases, and, possibly, oxidative stress through disulfide bond formation. Titin has also emerged as an important human disease gene. Early studies in patients with dilated cardiomyopathy (DCM) revealed shifts toward...

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Share to Heart Diseases
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Share to Myocytes, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Dilated

Share to Cardiomyopathy, Hypertrophic

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Share to Protein Processing, Post-Translational

Source

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Identifiers

PMID: 24072177
DOI: 10.1097/FJC.0000000000000007
PMCID: PMC4268868

Genes

RBM20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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