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Article

Mechanisms of genetic instability caused by (CGG)n repeats in an experimental mammalian system.

Nature structural & molecular biology - 1 Aug 2018

Kononenko Artem V, Ebersole Thomas, Vasquez Karen M, Mirkin Sergei M

Abstract excerpt

We developed an experimental system for studying genome instability caused by fragile X (CGG)n repeats in mammalian cells. Our method uses a selectable cassette carrying the HyTK gene under the control of the FMR1 promoter with (CGG)n repeats in its 5' UTR, which is integrated into the unique RL5 site in murine erythroid leukemia cells. Carrier-size (CGG)n repeats markedly elevated the frequency of reporter...

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Share to Fragile X Mental Retardation Protein
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 30061600
DOI: 10.1038/s41594-018-0094-9
PMCID: PMC6082162

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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