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Article

A dual-mode single-molecule fluorescence assay for the detection of expanded CGG repeats in Fragile X syndrome.

Molecular biotechnology - 1 Jan 2013

Cannon Brian, Pan Cynthia, Chen Liangjing, Hadd Andrew G, Russell Rick

Abstract excerpt

Fragile X syndrome is the leading cause of inherited mental impairment and is associated with expansions of CGG repeats within the FMR1 gene. To detect expanded CGG repeats, we developed a dual-mode single-molecule fluorescence assay that allows acquisition of two parallel, independent measures of repeat number based on (1) the number of Cy3-labeled probes bound to the repeat region and (2) the physical length of...

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Identifiers

PMID: 22311273
DOI: 10.1007/s12033-012-9505-z
PMCID: PMC3398218

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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