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Article

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.

Nucleic acids research - 1 Feb 2012

Sarkies Peter, Murat Pierre, Phillips Lara G, Patel K J, Balasubramanian Shankar, Sale Julian E

Abstract excerpt

We have previously reported that DT40 cells deficient in the Y-family polymerase REV1 are defective in replicating G-quadruplex DNA. In vivo this leads to uncoupling of DNA synthesis from redeposition of histones displaced ahead of the replication fork, which in turn leads to loss of transcriptional repression due to failure to recycle pre-existing repressive histone post-translational modifications. Here we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22021381
DOI: 10.1093/nar/gkr868
PMCID: PMC3287192

Genes

BLM
REV1
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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