Article
Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.
Mutation research - 1 Mar 2007
Russell Liane B, Hunsicker Patricia R, Russell William L
Abstract excerpt
Mutagenic, reproductive, and toxicity effects of two closely related chemicals, ethylnitrosourea (ENU) and methylnitrosourea (MNU), were compared at equimolar and near-equimolar doses in the mouse specific-locus test in a screen of all stages of spermatogenesis and spermiogenesis. In stem-cell spermatogonia (SG), ENU is more than an order of magnitude more mutagenic than MNU. During post-SG stages, both chemicals...
Topics
- Alkylating Agents
- Animals
- Ethylnitrosourea
- Germ-Line Mutation
- Male
- Methylnitrosourea
- Mice
- Mice, Inbred C3H
- Mutagenicity Tests
- Mutagens
- Mutation
- Spermatogenesis
- Spermatogonia