Article
A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells.
Mutation research - 15 Oct 2005
Yauk Carole L, Gingerich John D, Soper Lynda, MacMahon Avril, Foster Warren G, Douglas George R
Abstract excerpt
There is ongoing concern that an assay for germ cell effects in female animals is not available. While transgenic mutation detection systems provide unprecedented access to numerous rodent tissues, studies on the induction of gene mutations in oocytes are still not possible because sufficient numbers of cells cannot be harvested. However, following stimulation of an ovarian follicle, the granulosa cells contained...
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