Article
Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms.
Molecular and cellular biology - 1 Jul 2006
Viens Antoine, Mechold Undine, Brouillard Franck, Gilbert Cristele, Leclerc Philippe, Ogryzko Vasily
Abstract excerpt
Chromatin is considered to be a principal carrier of epigenetic information due to the ability of alternative chromatin states to persist through generations of cell divisions and to spread on DNA. Replacement histone variants are novel candidates for epigenetic marking of chromatin. We developed a novel approach to analyze the chromatin environment of nucleosomes containing a particular replacement histone. We...
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