Article
Comprehensive structural analysis of mutant nucleosomes containing lysine to glutamine (KQ) substitutions in the H3 and H4 histone-fold domains.
Biochemistry - 13 Sept 2011
Iwasaki Wakana, Tachiwana Hiroaki, Kawaguchi Koichiro, Shibata Takehiko, Kagawa Wataru, Kurumizaka Hitoshi
Abstract excerpt
Post-translational modifications (PTMs) of histones play important roles in regulating the structure and function of chromatin in eukaryotes. Although histone PTMs were considered to mainly occur at the N-terminal tails of histones, recent studies have revealed that PTMs also exist in the histone-fold domains, which are commonly shared among the core histones H2A, H2B, H3, and H4. The lysine residue is a major...
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