Article
The role of genetics in Parkinson's disease: a large cohort study in Chinese mainland population.
Brain : a journal of neurology - 1 Jul 2020
Zhao Yuwen, Qin Lixia, Pan Hongxu, Liu Zhenhua, Jiang Li, He Yan, Zeng Qian, Zhou Xun, Zhou Xiaoxia, Zhou Yangjie, Fang Zhenghuan, Wang Zheng, Xiang Yaqin, Yang Honglan, Wang Yige, Zhang Kailin, Zhang Rui, He Runcheng, Zhou Xiaoting, Zhou Zhou, Yang Nannan, Liang Dongxiao, Chen Juan, Zhang Xuxiang, Zhou Yao, Liu Hongli, Deng Penghui, Xu Kun, Xu Ke, Zhou Chaojun, Zhong Junfei, Xu Qian, Sun Qiying, Li Bin, Zhao Guihu, Wang Tao, Chen Ling, Shang Huifang, Liu Weiguo, Chan Piu, Xue Zheng, Wang Qing, Guo Li, Wang Xuejing, Xu Changshui, Zhang Zhentao, Chen Tao, Lei Lifang, Zhang Hainan, Wang Chunyu, Tan Jieqiong, Yan Xinxiang, Shen Lu, Jiang Hong, Zhang Zhuohua, Hu Zhengmao, Xia Kun, Yue Zhenyu, Li Jinchen, Guo Jifeng, Tang Beisha
Abstract excerpt
This study aimed to determine the mutational spectrum of familial Parkinson's disease and sporadic early-onset Parkinson's disease (sEOPD) in a mainland Chinese population and the clinical features of mutation carriers. We performed multiplex ligation-dependent probe amplification assays and whole-exome sequencing for 1676 unrelated patients with Parkinson's disease in a mainland Chinese population, including 192...
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