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Article

Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada.

PloS one - 1 Jan 2012

Ragonnet-Cronin Manon, Aris-Brosou Stéphane, Joanisse Isabelle, Merks Harriet, Vallee Dominic, Caminiti Kyna, Sandstrom Paul, Brooks James

Abstract excerpt

Host immune selection pressure influences the development of mutations that allow for HIV escape. Mutation patterns induced in HIV by the human leukocyte antigen (HLA) are HLA-allele specific. As ethnic groups have distinct and characteristic HLA allele frequencies, we can expect divergent viral evolution within ethnicities. Here, we have sequenced and analyzed the HIV pol gene from 1248 subtype B infected,...

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Identifiers

PMID: 22693560
DOI: 10.1371/journal.pone.0036933
PMCID: PMC3365047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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