Article

The ERCC6L2-MRI-KU complex coordinates NHEJ at staggered DNA double-strand breaks

2025-11-28

Abstract excerpt

ERCC6L2 disease is a recessive bone marrow failure (BMF) syndrome caused by mutations in the SNF2-like putative DNA helicase ERCC6L2. While implicated in DNA replication, double strand break (DSB) repair via non-homologous end joining (NHEJ), and interstrand crosslink (ICL) repair, how ERCC6L2 supports haematopoietic longevity remains unclear. Investigating this in vivo , we find that an Ercc6l2- deficient haema...

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Literature Corpus work: 3c3e83e2-44e6-5a91-9d8d-f1ce1c1d4207
DOI: 10.1101/2025.11.28.691009

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