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Germline mutations in PPFIBP2 are associated with lethal prostate cancer.

The Prostate - 1 Dec 2018

Wu Yishuo, Yu Hongjie, Zheng Siqun Lilly, Feng Bingjian, Kapron Ashley L, Na Rong, Boyle Julie L, Shah Sameep, Shi Zhuqing, Ewing Charles M, Wiley Kathleen E, Luo Jun, Walsh Patrick C, Carter Herbert Ballentine, Helfand Brian T, Cooney Kathleen A, Xu Jianfeng, Isaacs William B

Abstract excerpt

BACKGROUND: Few genes have germline mutations which predispose men to more aggressive prostate cancer (PCa). This study evaluated the contribution of germline loss of function (LOF) variants in PPFIBP2 to risk of lethal PCa. METHODS: A case-case study of 1414 PCa patients with lethal PCa and low-risk localized PCa was performed. Germline DNA samples from these patients were sequenced for PPFIBP2. Mutation carrier...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30043417
DOI: 10.1002/pros.23697

Genes

PPFIBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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