Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer

9 Mar 2018

Abstract excerpt

BACKGROUND: Germline mutations in CHEK2 have been associated with prostate cancer (PCa) risk. Our objective is to examine whether germline pathogenic CHEK2 mutations can differentiate risk of lethal from indolent PCa. METHODS: A case-case study of 703 lethal PCa patients and 1455 patients with low-risk localized PCa of European, African, and Chinese origin was performed. Germline DNA samples from these patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29520813
DOI: 10.1002/pros.23505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancerPMID 29520813Read ↗

Germline mutations in PPFIBP2 are associated with lethal prostate cancer.Semantic proximity Read ↗

Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).Semantic proximity Read ↗

Mutations in CHEK2 associated with prostate cancer risk.Semantic proximity Read ↗

Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer.Semantic proximity Read ↗

Genomic Ascertainment of CHEK2-Related Cancer Predisposition.Semantic proximity Read ↗

Detection of Germline Variants in Patients With Localized and Metastatic Prostate Cancer Through Guideline-Based Testing.Semantic proximity Read ↗

Association of Inherited Pathogenic Variants in Checkpoint Kinase 2 (CHEK2) With Susceptibility to Testicular Germ Cell TumorsSemantic proximity Read ↗

Germline genetic variants in men with prostate cancer and one or more additional cancers.Semantic proximity Read ↗

Recent Insights on Genetic Testing in Primary Prostate Cancer.Semantic proximity Read ↗

Germline variants in early and late-onset Brazilian prostate cancer patients.Semantic proximity Read ↗

Prevalence and Clinical Impact of Germline Pathogenic Variants in Breast Cancer Susceptibility Genes among Chinese Male Patients with Breast CancerSemantic proximity Read ↗

Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.