Article
Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.
PloS one - 1 Jan 2015
Amend Sarah R, Wilson William C, Chu Liang, Lu Lan, Liu Pengyuan, Serie Daniel, Su Xinming, Xu Yalin, Wang Dingyan, Gramolini Anthony, Wen Xiao-Yan, O'Neal Julie, Hurchla Michelle, Vachon Celine M, Colditz Graham, Vij Ravi, Weilbaecher Katherine N, Tomasson Michael H
Abstract excerpt
Monoclonal gammopathy of undetermined significance (MGUS) is the requisite precursor to multiple myeloma (MM), a malignancy of antibody-producing plasma B-cells. The genetic basis of MGUS and its progression to MM remains poorly understood. C57BL/KaLwRij (KaLwRij) is a spontaneously-derived inbred mouse strain with a high frequency of benign idiopathic paraproteinemia (BIP), a phenotype with similarities to MGUS...
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