A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages

doi:10.1186/s13045-024-01629-3

Article

A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages

7 Nov 2024

Abstract excerpt

BACKGROUND: The long-term effectiveness of immunotherapies against Multiple Myeloma (MM) remains elusive, demonstrated by the inevitable relapse in patients. This underscores the urgent need for an in-depth analysis of the MM tumor-immune microenvironment (TME). Hereto, a representative immunocompetent MM mouse model can offer a valuable approach to study the dynamic changes within the MM-TME and to uncover...

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