Article

Macrophage is vital for C5b-9-induced cyst formation and enlargement in Pkd1 -/- mice

2023-06-10

Abstract excerpt

C5b-9 complex, the final product of complement, is overproduced during cystogenesis in the kidneys of rapid-onset mice with Pkd 1 gene deficiency at postnatal day (PD)10. Compared with rapid-onset polycystic kidney disease (PKD) model, cyst enlargement is much less progressive in mice when Pkd 1 gene inactivation at PD30 (chronic-onset model); however, C5b-9 infusion significantly accelerated ADPKD progression in...

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Literature Corpus work: 104a979f-a42f-55cb-8a82-1bc9c3cfbf50
DOI: 10.21203/rs.3.rs-3027711/v1

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