Article
Macrophages promote polycystic kidney disease progression.
Kidney international - 1 May 2013
Swenson-Fields Katherine I, Vivian Carolyn J, Salah Sally M, Peda Jacqueline D, Davis Bradley M, van Rooijen Nico, Wallace Darren P, Fields Timothy A
Abstract excerpt
Renal M2-like macrophages have critical roles in tissue repair, stimulating tubule cell proliferation and, if they remain, fibrosis. M2-like macrophages have also been implicated in promoting cyst expansion in mouse models of autosomal dominant polycystic kidney disease (ADPKD). While renal macrophages have been documented in human ADPKD, there are no studies in autosomal recessive polycystic kidney disease...
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