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Article

Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma.

BMC cancer - 24 Jul 2018

Ma Jie, Fu Yong, Tu Yao-Yao, Liu Ying, Tan Yi-Ran, Ju Wu-Tong, Pickering Curtis R, Myers Jeffrey N, Zhang Zhi-Yuan, Zhong Lai-Ping

Abstract excerpt

BACKGROUND: With the development of sequencing technologies, there may be some disputes on sequencing analysis. The aim of this study was to investigate different allele frequency thresholds of mutations in targeted genes on prognostic analyses using a panel of cancer associated gene exons (CAGE) in oral squamous cell carcinoma (OSCC). METHODS: Forty-six patients were included in this study. Twelve genes were...

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Identifiers

PMID: 30041611
DOI: 10.1186/s12885-018-4481-8
PMCID: PMC6057048

Genes

CASP8
CDH1
NOTCH1

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