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Article

Noninvasive genomic profiling of somatic mutations in oral cavity cancers.

Oral oncology - 1 May 2023

Xi Yuanxin, Negrao Marcelo V, Akagi Keiko, Xiao Weihong, Jiang Bo, Warner Sarah C, Dunn Joe Dan, Wang Jing, Symer David E, Gillison Maura L

Abstract excerpt

OBJECTIVES: Somatic mutations may predict prognosis, therapeutic response, or cancer progression. We evaluated targeted sequencing of oral rinse samples (ORS) for non-invasive mutational profiling of oral squamous cell carcinomas (OSCC). MATERIALS AND METHODS: A custom hybrid capture panel targeting 42 frequently mutated genes in OSCC was used to identify DNA sequence variants in matched ORS and fresh-frozen...

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Identifiers

PMID: 37004423
DOI: 10.1016/j.oraloncology.2023.106372
PMCID: PMC10367182

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