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Article

Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer's Disease.

Neuroscience bulletin - 1 Dec 2018

Wang Dongpi, Zhang Xiaoqin, Wang Mingkai, Zhou Dongming, Pan Hongyu, Shu Qiang, Sun Binggui

Abstract excerpt

Astrocytes are closely associated with Alzheimer's disease (AD). However, their precise roles in AD pathogenesis remain controversial. One of the reasons behind the different results reported by different groups might be that astrocytes were targeted at different stages of disease progression. In this study, by crossing hAPP (human amyloid precursor protein)-J20 mice with a line of GFAP-TK mice, we found that...

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Source

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Identifiers

PMID: 30032411
DOI: 10.1007/s12264-018-0262-2
PMCID: PMC6246842

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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