Back to search

Article

Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure

2020-02-24

Abstract excerpt

<title>Abstract</title> <p>Background Early-life stress (ES) is an emerging risk factor for later-life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 mouse model. Because astrocytes are key players in the pathogenesis of AD, we studied here if and how ES affects astrocytes in wildtype (WT) and APP/PS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
42bcbfca-d010-5900-a36c-8501fd2c4b19
DOI
10.21203/rs.2.18902/v3
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposureDOI 10.21203/rs.2.18902/v3
Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in <i>APP</i> <sub>Swe</sub> / <i>PSEN1</i> <sub>M146V</sub> transgenic miceSemantic proximity
Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteinsSemantic proximity
The Role of Astrocytes in the Temporoammonic Pathway: Masticatory Behavior as a Neuroprotective Strategy Against Age-Related Cognitive DeclineSemantic proximity
Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal CortexSemantic proximity
Morphofunctional Investigation in a Transgenic Mouse Model of Alzheimer’s Disease: Non-Reactive Astrocytes Are Involved in Aβ Load and Reactive Astrocytes in Plaque Build-UpSemantic proximity
Aβ-induced distress of astrocytes triggers Alzheimer disease pathology through non-canonical δ secretase activitySemantic proximity
Deletion of astrocyte intermediate filaments GFAP and Vimentin enhances protein synthesis and prevents early synaptic and cognitive dysfunction in a mouse model of Alzheimer’s diseaseSemantic proximity
Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer's disease neuropathology in APPSwe/PS1A246E transgenic mice.Semantic proximity
Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's diseaseSemantic proximity
Divergent Effects of <i>APOE3</i> and <i>APOE4</i> Human Astrocytes on Key Alzheimer’s Disease Hallmarks in Chimeric MiceSemantic proximity
Cortical astrocytes control stress resilienceSemantic proximity
Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer’s Disease: Implications for Controlling Astroglial ActivitySemantic proximity
Select a neighboring publication to make it the new centre.