Article
OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction.
Cardiovascular research - 1 Dec 2018
van der Pol Atze, Gil Andres, Tromp Jasper, Silljé Herman H W, van Veldhuisen Dirk J, Voors Adriaan A, Hoendermis Elke S, Grote Beverborg Niels, Schouten Elisabeth-Maria, de Boer Rudolf A, Bischoff Rainer, van der Meer Peter
Abstract excerpt
Aims: The prevalence of heart failure with a preserved ejection fraction (HFpEF) is increasing, but therapeutic options are limited. Oxidative stress is suggested to play an important role in the pathophysiology of HFpEF. However, whether oxidative stress is a bystander due to comorbidities or causative in itself remains unknown. Recent results have shown that depletion of 5-oxoprolinase (OPLAH) leads to...
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