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Article

Defining HFpEF in rodents: a systematic review.

Cardiovascular research - 22 Nov 2025

Adrah Yamen, Hegemann Niklas, Faidel David, Kucherenko Mariya M, Kuebler Wolfgang M, Schiattarella Gabriele G, Beyhoff Niklas, Grune Jana

Abstract excerpt

AIMS: Heart failure (HF) with preserved ejection fraction (HFpEF) has become the most diagnosed HF subtype representing a major public health burden with poor clinical outcome. Available treatment options for HFpEF are limited; hence, more in-depth basic/translational research is needed to identify novel therapeutic targets. Preclinical investigations frequently rely on mice and rat models of HFpEF, yet their...

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PMID: 40997162
DOI: 10.1093/cvr/cvaf174

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