Article
EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.
Journal of the American College of Cardiology - 15 Aug 2006
van Empel Vanessa P M, Bertrand Anne T, van Oort Ralph J, van der Nagel Roel, Engelen Markus, van Rijen Harold V, Doevendans Pieter A, Crijns Harry J, Ackerman Susan L, Sluiter Wim, De Windt Leon J
Abstract excerpt
OBJECTIVES: The purpose of this study was to identify apoptosis-inducing factor (AIF) as a cardiac mitochondrial antioxidant and assess the efficacy of EUK-8, a salen-manganese catalytic free radical scavenger, to protect the AIF-deficient myocardium against pressure overload. BACKGROUND: Oxidative stress has been postulated to provoke cell death and pathologic remodeling in heart failure. We recently...
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