Linking amyotrophic lateral sclerosis and spinal muscular atrophy through <scp>RNA</scp>‐transcriptome homeostasis: a genomics perspective

Abstract excerpt

In this review, we present our most recent understanding of key biomolecular processes that underlie two motor neuron degenerative disorders, amyotrophic lateral sclerosis, and spinal muscular atrophy. We focus on the role of four multifunctional proteins involved in RNA metabolism (TDP-43, FUS, SMN, and Senataxin) that play a causal role in these diseases. Recent results have led to a novel scenario of intricate...

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