Article
Association of Transforming Growth Factor β Polymorphism C-509T With Radiation-Induced Fibrosis Among Patients With Early-Stage Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
JAMA oncology - 1 Dec 2018
Grossberg Aaron J, Lei Xiudong, Xu Ting, Shaitelman Simona F, Hoffman Karen E, Bloom Elizabeth S, Stauder Michael C, Tereffe Welela, Schlembach Pamela J, Woodward Wendy A, Buchholz Thomas A, Smith Benjamin D
Abstract excerpt
Importance: Whether genetic factors can identify patients at risk for radiation-induced fibrosis remains unconfirmed. Objective: To assess the association between the C-509T variant allele in the promoter region of TGFB1 and breast fibrosis 3 years after radiotherapy. Design, Setting, and Participants: This is an a priori-specified, prospective, cohort study nested in an open-label, randomized clinical trial,...
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