Article
Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2012
Ma Xiangyu, Beeghly-Fadiel Alicia, Lu Wei, Shi Jiajun, Xiang Yong-Bing, Cai Qiuyin, Shen Hongbing, Shen Chen-Yang, Ren Zefang, Matsuo Keitaro, Khoo Ui Soon, Iwasaki Motoki, Long Jirong, Zhang Ben, Ji Bu-Tian, Zheng Ying, Wang Wenjing, Hu Zhibin, Liu Yao, Wu Pei-Ei, Shieh Ya-Lan, Wang Shenming, Xie Xiaoming, Ito Hidemi, Kasuga Yoshio, Chan Kelvin Y K, Iwata Hiroji, Tsugane Shoichiro, Gao Yu-Tang, Shu Xiao Ou, Moses Harold L, Zheng Wei
Abstract excerpt
BACKGROUND: The TGF-β signaling pathway plays a significant role in the carcinogenic process of breast cancer. METHODS: We systematically evaluated associations of common variants in TGF-β signaling pathway genes with breast cancer risk using a multistage, case-control study among Asian women. RESULTS: In the first stage, 341 single-nucleotide polymorphisms with minor allele frequencies ≥ 0.05 across 11 genes...
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