Article
Test of association between variant tgβ1 alleles and late adverse effects of breast radiotherapy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 2010
Martin Susan, Sydenham Mark, Haviland Joanne, A'Hern Roger, Owen Roger, Bliss Judith, Yarnold John
Abstract excerpt
PURPOSE: To test for association between single nucleotide polymorphisms at the TGFβ1 locus and the risk of late normal tissue injury following whole breast radiotherapy. METHODS: A retrospective study compared the number of variant alleles at -509 and codons 10 and 25 of the TGFβ1 locus in women followed up in two prospective clinical trials who developed either marked radiotherapy adverse effects or no adverse...
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