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Article

Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients.

International journal of radiation oncology, biology, physics - 1 Jun 2012

Terrazzino Salvatore, La Mattina Pierdaniele, Gambaro Giuseppina, Masini Laura, Franco Pierfrancesco, Canonico Pier Luigi, Genazzani Armando A, Krengli Marco

Abstract excerpt

PURPOSE: To provide new insights into the genetic basis of normal tissue radiosensitivity, we evaluated the association between eight polymorphic variants located in six genes related to DNA repair mechanisms, oxidative stress, and fibroblast proliferation (XRCC1 Arg399Gln, XRCC1 Arg194Trp, TP53 Arg72Pro, GSTP1 Ile105Val, GSTA1 C-69T, eNOS G894T, TGFβ1 C-509T, and TGFβ1 T869C) and the risk of subcutaneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22079734
DOI: 10.1016/j.ijrobp.2011.06.2012

Genes

GSTA1
GSTP1
XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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