Article
No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 2010
Barnett Gillian C, Coles Charlotte E, Burnet Neil G, Pharoah Paul D P, Wilkinson Jennifer, West Catharine M L, Elliott Rebecca M, Baynes Caroline, Dunning Alison M
Abstract excerpt
BACKGROUND AND PURPOSE: Several small studies have reported associations between TGFB1 single nucleotide polymorphisms (SNPs), considered to increase secretion of TGF-β1, and greater than 3-fold increases in incidence of fibrosis - an indicator of late toxicity after radiotherapy in breast cancer patients. MATERIALS AND METHODS: Two SNPs in TGFB1, C-509T (rs1800469) and L10P (rs1800470), were genotyped in 778...
Read the complete abstract on PubMed