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Article

No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 2010

Barnett Gillian C, Coles Charlotte E, Burnet Neil G, Pharoah Paul D P, Wilkinson Jennifer, West Catharine M L, Elliott Rebecca M, Baynes Caroline, Dunning Alison M

Abstract excerpt

BACKGROUND AND PURPOSE: Several small studies have reported associations between TGFB1 single nucleotide polymorphisms (SNPs), considered to increase secretion of TGF-β1, and greater than 3-fold increases in incidence of fibrosis - an indicator of late toxicity after radiotherapy in breast cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20096948
DOI: 10.1016/j.radonc.2009.12.006
PMCID: PMC3120654

Genes

TGFB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20096948-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study.PMID 20096948Read ↗

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.Semantic proximity Read ↗

Association of Transforming Growth Factor β Polymorphism C-509T With Radiation-Induced Fibrosis Among Patients With Early-Stage Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.Semantic proximity Read ↗

Test of association between variant tgβ1 alleles and late adverse effects of breast radiotherapy.Semantic proximity Read ↗

No association between TGFB1 polymorphisms and late radiotherapy toxicity: a meta-analysis.Semantic proximity Read ↗

Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patientsSemantic proximity Read ↗

The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes.Semantic proximity Read ↗

Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients.Semantic proximity Read ↗

No effect of the transforming growth factor β1 promoter polymorphism C-509T on TGFB1 gene expression, protein secretion, or cellular radiosensitivity.Semantic proximity Read ↗

Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients.Semantic proximity Read ↗

TGFBR1*6A and breast tumor fibrosisSemantic proximity Read ↗

Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial.Semantic proximity Read ↗

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