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Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism

15 Jun 2024

Abstract excerpt

The transcriptional coactivator PGC-1α has been implicated in the regulation of multiple metabolic processes. However, the previously reported metabolic phenotypes of mice deficient in PGC-1α have been inconsistent. PGC-1α exists as multiple isoforms, including variants transcribed from an alternative first exon. We show here that alternative PGC-1α variants are the main entity that increases PGC-1α during...

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PMID: 38885788
DOI: 10.1016/j.molmet.2024.101968

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