Article
Sirt1 protects from K-Ras-driven lung carcinogenesis.
EMBO reports - 1 Sept 2018
Costa-Machado Luis Filipe, Martín-Hernández Roberto, Sanchez-Luengo Miguel Ángel, Hess Katharina, Vales-Villamarin Claudia, Barradas Marta, Lynch Cian, de la Nava Daniel, Diaz-Ruiz Alberto, de Cabo Rafael, Cañamero Marta, Martinez Lola, Sanchez-Carbayo Marta, Herranz Daniel, Serrano Manuel, Fernandez-Marcos Pablo J
Abstract excerpt
The NAD+-dependent deacetylase SIRT1 can be oncogenic or tumor suppressive depending on the tissue. Little is known about the role of SIRT1 in non-small cell lung carcinoma (NSCLC), one of the deadliest cancers, that is frequently associated with mutated K-RAS Therefore, we investigated the effect of SIRT1 on K-RAS-driven lung carcinogenesis. We report that SIRT1 protein levels are downregulated by oncogenic...
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