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Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer

30 Sept 2013

Abstract excerpt

Aging is the strongest risk factor for cancer development, suggesting that molecular crosstalks between aging and tumorigenesis exist in many cellular pathways. Recently, Sirtuins (Sirt1-7), the mammalian homologues of aging-related sir2α in yeast, have been shown to modulate several major cellular pathways, such as DNA repair, inflammation, metabolism, cell death, and proliferation in response to diverse...

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PMID: 24064057
DOI: 10.5483/bmbrep.2013.46.9.180

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