Article

Targeting TGF-β-Smad2/3-JNK1-mediated SIRT1 activity overcomes the chemoresistance of KRAS mutation lung cancer

2024-11-20

Abstract excerpt

<title>Abstract</title> <p>Lung cancer patients with a KRAS oncogenic driver mutation have a very poor prognosis. Recently, we reported that SIRT1 is upregulated by the KRAS<sup>Mut</sup>-c-Myc-axis and KRAS<sup>Mut</sup>-induced SIRT1 stably deacetylated by lysine 104 and increased KRAS<sup>Mut</sup> activity, enhancing chemoresistance. Of note, SIRT1 activity, as well as SIRT1 levels are more increased in KRAS<...

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Literature Corpus work: 0116388d-244c-5f91-8e1e-5619cb4b7605
DOI: 10.21203/rs.3.rs-5237268/v1

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