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Article

The Roles of SIRT1 in Cancer

29 Jan 2013

Abstract excerpt

The sirtuin family has emerged as important regulators of diverse physiological and pathological events, including life-span extension, neurodegeneration, age-related disorders, obesity, heart disease, inflammation, and cancer. In mammals, there are 7 members (SIRT1-SIRT7) in the sirtuin family, with the function of SIRT1 being extensively studied in the past decade. SIRT1 can deacetylate histones and a number of...

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PMID: 24020000
DOI: 10.1177/1947601912475079

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