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Article

The emerging and diverse roles of sirtuins in cancer: a clinical perspective

1 Oct 2013

Abstract excerpt

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein lysine modifying enzymes with deacetylase, adenosine diphosphateribosyltransferase and other deacylase activities. Mammals have seven sirtuins, namely SIRT1-7. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress...

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PMID: 24133372
DOI: 10.2147/ott.s37750

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