Article

Interactome Analysis of the CC2D1A Scaffold Reveals Novel Neuronal Interactions and a Postsynaptic Role

2025-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Loss of the protein scaffold Coiled-coil and C2 domain containing 1A (CC2D1A) leads to intellectual disability (ID), autism spectrum disorder (ASD), and other neurodevelopmental presentations in humans. CC2D1A interactions have been studied in different cell lines proposing diverse roles in endolysosomal maturation and intracellular signaling, but the composition and functional mechanisms of the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c1b2ee2-519d-5022-8c44-fba72463c33a
DOI: 10.1101/2025.06.26.661826

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interactome Analysis of the CC2D1A Scaffold Reveals Novel Neuronal Interactions and a Postsynaptic RoleDOI 10.1101/2025.06.26.661826Read

Endogenous Protein-Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex.Semantic proximity Read

CC2D1A regulates human intellectual and social function as well as NF-κB signaling homeostasis.Semantic proximity Read

A synthesis of over 9,000 mass spectrometry experiments reveals the core set of human protein complexesSemantic proximity Read

<i>In Silico</i> Structure-Based Interactomic Analysis of the Scaffolding Protein DCAF7Semantic proximity Read

Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer DiseaseSemantic proximity Read

Interaction studies of risk proteins in human induced neurons reveal convergent biology and novel mechanisms underlying autism spectrum disordersSemantic proximity Read

Structural characterization of the human CC2D1A fragment associated with non-syndromic intellectual disability (NSID).Semantic proximity Read

PACS1 syndrome variant alters proteomic landscape of developing cortical organoidsSemantic proximity Read

Joubert syndrome causing mutation in C2 domain of CC2D2A affects structural integrity of cilia and cellular signaling molecules.Semantic proximity Read

Reduced MUNC18-1 Levels, Synaptic Proteome Changes, and Altered Network Activity in STXBP1-Related Disorder Patient NeuronsSemantic proximity Read

CC2D1A causes ciliopathy, intellectual disability, heterotaxy, renal dysplasia, and abnormal CSF flow.Semantic proximity Read

Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondriaSemantic proximity Read