Article
The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.
Developmental cell - 25 Jan 2016
Li Shuijie, Fell Stuart M, Surova Olga, Smedler Erik, Wallis Karin, Chen Zhi Xiong, Hellman Ulf, Johnsen John Inge, Martinsson Tommy, Kenchappa Rajappa S, Uhlén Per, Kogner Per, Schlisio Susanne
Abstract excerpt
KIF1Bβ is a candidate 1p36 tumor suppressor that regulates apoptosis in the developing sympathetic nervous system. We found that KIF1Bβ activates the Ca(2+)-dependent phosphatase calcineurin (CN) by stabilizing the CN-calmodulin complex, relieving enzymatic autoinhibition and enabling CN substrate recognition. CN is the key mediator of cellular responses to Ca(2+) signals and its deregulation is implicated in...
Topics
- Apoptosis
- Calcineurin
- Dynamins
- GTP Phosphohydrolases
- Genes, Tumor Suppressor
- Humans
- Kinesins
- Microtubule-Associated Proteins
- Mitochondrial Dynamics
- Mitochondrial Proteins
- Mutation
- Neuroblastoma
- Phosphorylation