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Article

LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis patients.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Oct 2018

Bernardes M, Durães C, Oliveira A, Martins M J, Lucas R, Costa L, Pereira J G, Ramos I, Machado J C, Simões-Ventura F

Abstract excerpt

Rheumatoid arthritis (RA) is characterized by increased bone resorption and impaired bone formation. Osteoblast function is regulated by the canonical LRP5/Wnt/β-catenin pathway. Bone mineral density and RA joint destruction are partially inherited. In line with this, we found significant associations between LRP5 SNPs (p.A1330V, p.N740N, p.V667M) and RA radiographic damage severity. INTRODUCTION: Increased bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30019084
DOI: 10.1007/s00198-018-4625-3

Genes

LRP5

Variants

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