Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis?

Osteoarthritis and cartilage - 1 Jul 2005

Smith A J P, Gidley J, Sandy J R, Perry M J, Elson C J, Kirwan J R, Spector T D, Doherty M, Bidwell J L, Mansell J P

Abstract excerpt

OBJECTIVE: Several genome-wide scans have revealed an osteoarthritis (OA)-susceptibility locus on chromosome 11q in close proximity to the low-density lipoprotein receptor-related protein 5 (LRP5) gene. The regulation of bone mass is under the control of LRP5 and since increased bone mass is thought to play a role in the pathology of OA we examined LRP5 polymorphisms and haplotypes to determine if variants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Density
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to LDL-Receptor Related Proteins

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Osteoarthritis

Share to Receptors, LDL

Share to United Kingdom

Source

Identifiers

PMID: 15979013
DOI: 10.1016/j.joca.2005.01.008

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis?PMID 15979013Read ↗

A haplotype-based analysis of the LRP5 gene in relation to osteoporosis phenotypes in Spanish postmenopausal women.Semantic proximity Read ↗

Evaluation of the association between a single-nucleotide polymorphism of bone morphogenetic proteins 5 gene and risk of knee osteoarthritis.Semantic proximity Read ↗

Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass.Semantic proximity Read ↗

Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study.Semantic proximity Read ↗

Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men.Semantic proximity Read ↗

Q89R Polymorphism in the LDL Receptor-Related Protein 5 Gene Is Associated With Spinal Osteoarthritis in Postmenopausal Japanese WomenSemantic proximity Read ↗

Genetic epidemiology of hip and knee osteoarthritis.Semantic proximity Read ↗

Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men.Semantic proximity Read ↗

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritisSemantic proximity Read ↗

Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis.Semantic proximity Read ↗

Association of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal women.Semantic proximity Read ↗

Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.