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Article

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.

Diabetologia - 1 Sept 2016

Semplici Francesca, Mondragon Angeles, Macintyre Benedict, Madeyski-Bengston Katja, Persson-Kry Anette, Barr Sara, Ramne Anna, Marley Anna, McGinty James, French Paul, Soedling Helen, Yokosuka Ryohsuke, Gaitan Julien, Lang Jochen, Migrenne-Li Stephanie, Philippe Erwann, Herrera Pedro L, Magnan Christophe, da Silva Xavier Gabriela, Rutter Guy A

Abstract excerpt

AIMS/HYPOTHESIS: Per-Arnt-Sim kinase (PASK) is a nutrient-regulated domain-containing protein kinase previously implicated in the control of insulin gene expression and glucagon secretion. Here, we explore the roles of PASK in the control of islet hormone release, by generating mice with selective deletion of the Pask gene in pancreatic beta or alpha cells. METHODS: Floxed alleles of Pask were produced by...

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Identifiers

PMID: 27338626
DOI: 10.1007/s00125-016-4025-1
PMCID: PMC4969360

Genes

PASK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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