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Article

Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.

PloS one - 3 Aug 2010

Bernal-Mizrachi Ernesto, Cras-Méneur Corentin, Ye Bo Ra, Johnson James D, Permutt M Alan

Abstract excerpt

BACKGROUND: Glucose modulates beta-cell mass and function through an initial depolarization and Ca(2+) influx, which then triggers a number of growth regulating signaling pathways. One of the most important downstream effectors in Ca(2+) signaling is the calcium/Calmodulin activated serine threonine phosphatase, calcineurin. Recent evidence suggests that calcineurin/NFAT is essential for beta-cell proliferation,...

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Identifiers

PMID: 20689817
DOI: 10.1371/journal.pone.0011969
PMCID: PMC2914754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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