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Article

Biallelic tumour suppressor loss and DNA repair defects in de novo small-cell prostate carcinoma.

The Journal of pathology - 1 Oct 2018

Chedgy Edmund Cp, Vandekerkhove Gillian, Herberts Cameron, Annala Matti, Donoghue Adam J, Sigouros Michael, Ritch Elie, Struss Werner, Konomura Saki, Liew Janet, Parimi Sunil, Vergidis Joanna, Hurtado-Coll Antonio, Sboner Andrea, Fazli Ladan, Beltran Himisha, Chi Kim N, Wyatt Alexander W

Abstract excerpt

Small-cell prostate carcinoma (SCPC) is an aggressive malignancy that is managed similarly to small-cell lung cancer. SCPC can evolve from prostate adenocarcinoma in response to androgen deprivation therapy, but, in rare cases, is present at initial cancer diagnosis. The molecular aetiology of de novo SCPC is incompletely understood, owing to the scarcity of tumour tissue and the short life-expectancy of...

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Identifiers

PMID: 30015382
DOI: 10.1002/path.5137

Genes

ATM
BRCA1
BRCA2
MSH2
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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