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Chromothripsis-Mediated Small Cell Lung Carcinoma

26 Aug 2024

Abstract excerpt

Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we performed detailed clinicopathologic, genomic, and transcriptomic profiling of an atypical subset of SCLC that lacked RB1 and TP53 co-inactivation and arose in never/light smokers. We found that most cases were associated with...

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PMID: 39185963
DOI: 10.1158/2159-8290.cd-24-0286

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