Article
Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate.
The Prostate - 1 May 2009
Hansel Donna E, Nakayama Masashi, Luo Jun, Abukhdeir Abde M, Park Ben H, Bieberich Charles J, Hicks Jessica L, Eisenberger Mario, Nelson William G, Mostwin Jasek L, De Marzo Angelo M
Abstract excerpt
BACKGROUND: Small cell carcinoma of the prostate is an uncommon neoplasm, the origin of which has been controversial. To address this, we performed transcriptome profiling and TP53 sequencing of concurrent small cell and prostatic adenocarcinoma to determine the relationship between these entities. METHODS: We identified an unusual case of primary prostate cancer that contained adjacent acinar adenocarcinoma...
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