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Article

Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer

16 Jul 2018

Abstract excerpt

BACKGROUND: The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer. MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened cellular glucose uptake in consort with increased flux through glycolysis, followed by the...

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PMID: 30012170
DOI: 10.1186/s12943-018-0851-8

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